Hormesis

Hormesis is a Fundamental Biological Concept

“The hormetic dose response is independent of biology model (i.e. common from plants to humans), and describes the limits to which integrative endpoints (e.g. cell proliferation, cell migration, growth patterns, tissue repair, aging processes, complex behaviors such as anxiety, learning, memory, and stress, preconditioning responses, and numerous adaptive responses) can be modulated. Thus, the hormesis concept is a fundamental concept in biology with a wide range of biological implications and biomedical applications.”

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354598/

Hormesis

Eating Fewer Meals Reduces Insulin Resistance

“Frequency of meals is an important aspect of nutrition, with profound effects on human health and lifespan. Reduced meal frequency can prevent the development of chronic diseases and extend the lifespan in laboratory animals due to lower oxidative damage and higher stress resistance. Intermittent fasting leads to a prolonged lifespan and positively affects glucose tolerance, insulin sensitivity and incidence of type 2 diabetes

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4079942/

Hormesis

Adapting to Physical and Environmental Challenges Combats Aging and Diseases

“An important feature of such evolutionary development is that certain level of external challenging became a necessary condition of organisms’ “normal” functioning. Such challenging activates defense mechanisms, which provide efficient protection not only from consequences of harmful external disturbances, but also from action of deleterious processes of internal origin e.g. aging, disease development.”

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2836145/

Hormesis

Hormesis Helps Us Cope with Aging and Disease

“The phenomenon termed hormesis describes an evolutionarily conserved process by which a cell or an entire organism can be preconditioned…Growing evidence suggests that hormesis is directly linked to an organism’s (or cell’s) capability to cope with pathological conditions such as aging and age-related diseases.”

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354599/

Hormesis

Challenging Oneself Intermittently Improves Health

“Humans and their predecessors evolved in environments where they were challenged intermittently…Cells and organ systems acquired and retained molecular signaling and metabolic pathways through which the environmental challenges enhanced the functionality and resilience of the cells and organisms…Within the past 60 years there has been a precipitous diminution of such challenges in modern societies…Signaling pathways that mediate beneficial effects of environmental challenges on health and disease resistance are disengaged, thereby rendering people vulnerable to obesity, diabetes, cardiovascular disease, cancers and neurodegenerative disorders.”

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4267452/

Hormesis

The Ability to Adapt is Critical to Our Health as We Age

“Adaptive homeostasis enables biological systems to make continuous short‐term adjustments for optimal functioning despite ever‐changing internal and external environments… One hallmark of the ageing process is a significant decline in adaptive homeostasis capacity…Aged organisms must therefore cope with higher levels of chronic low‐grade stress…We suggest that a potentially new avenue for assessing the ageing process would be to monitor the loss of adaptive homeostasis.”

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5730851/