“An important feature of such evolutionary development is that certain level of external challenging became a necessary condition of organisms’ “normal” functioning. Such challenging activates defense mechanisms, which provide efficient protection not only from consequences of harmful external disturbances, but also from action of deleterious processes of internal origin e.g. aging, disease development.”

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2836145/

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