“Adaptive homeostasis enables biological systems to make continuous short‐term adjustments for optimal functioning despite ever‐changing internal and external environments… One hallmark of the ageing process is a significant decline in adaptive homeostasis capacity…Aged organisms must therefore cope with higher levels of chronic low‐grade stress…We suggest that a potentially new avenue for assessing the ageing process would be to monitor the loss of adaptive homeostasis.”

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5730851/

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